Download Advanced Techniques in Dermatologic Surgery (Basic and by Goldman M.P. (Editor), Weiss R. (Editor) PDF

By Goldman M.P. (Editor), Weiss R. (Editor)

Compiled through professional specialists within the box, this reference presents transparent advice at the uncomplicated rules, approaches, and issues all for complicated dermatologic surgery-offering distinctive insurance of filling elements, fats move strategies, and the newest laser applied sciences.

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Extra info for Advanced Techniques in Dermatologic Surgery (Basic and Clinical Dermatology)

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BOTULINUM NEUROTOXINS Botulinum neurotoxins (BTXs) derive from the bacterium Clostridium botulinum and include seven distinct serotypes, identified as A, B, C1, D, E, F, and G. All BTX subtypes block neuromuscular transmission by binding to receptor sites on motor nerve terminals and inhibiting the release of acetylcholine, but differ slightly in their mechanism of action and clinical effect (1). When injected intramuscularly at therapeutic doses, BTXs produce temporary chemodenervation of the muscle, 19 20 Carruthers and Carruthers resulting in a localized reduction in muscle activity.

S. Food and Drug Administration. Since each preparation differs in terms of the C. botulinum strain, potency, and manufacturing, the biological behaviors of each are not interchangeable, and the dosages for each product vary. Comparative Effects of Botulinum Types A and B BTX-A has been used for aesthetic purposes for over a decade. Numerous clinical trials have established its safety and efficacy for hyperfunctional facial lines; the largest trial documented its superior efficacy over placebo in the treatment of glabellar rhytides, and led to the approval of BTX-A as the only botulinum toxin indicated for cosmetic use in North America (2).

S-CAINE LOCAL ANESTHETIC PEEL The S-Caine Local Anesthetic Peel contains a formulation of a 1:1 eutectic mixture of 7% lidocaine base and 7% TetracaineÕ base, similar to that of the S-Caine Patch (Table 1). The Peel is a cream which, as it dries, becomes a flexible membrane that is easily removed (Figs. 5 and 6). These unique features of the drug reduce the application time, ease the delivery of anesthetic to contoured regions of the body, and eliminate the need for application under occlusion. Phase II FDA studies have demonstrated that a 30-minute application of the S-Caine Peel is efficacious in relieving the pain caused by various laser procedures.

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